Tumor microenvironment: The culprit for ovarian cancer metastasis?
Publication/Presentation Date
7-28-2016
Abstract
Despite chemotherapy and surgical debulking options, ovarian cancer recurs and disseminates frequently, with poor prognosis. However, the molecular mechanisms underlying ovarian cancer metastasis still remain unelucidated. The tumor microenvironment, consisting of stromal cells (including fibroblasts, macrophages, regulatory T cells, myeloid-derived suppressor cells, endothelial cells, pericytes and platelets), the extracellular matrix component (EMC) (including inflammatory cytokines, chemokines, matrix metalloproteinases, integrins, and other secreted molecules) and exosomes (small extracellular vesicles loaded with molecules), establishes an autocrine-paracrine communication circuit that reinforces invasion and cancer cell metastasis via reciprocal signaling. Recent evidences have unraveled the significant contribution of tumor microenvironment to ovarian cancer metastasis. In this review, we provide a comprehensive landscape of the reciprocity between tumor stroma and ovarian cancer cells upon metastasis, aiming to offer novel clues on the development of novel diagnostic biomarkers and therapeutic targets for ovarian cancer in future clinical practice.
Volume
377
Issue
2
First Page
174
Last Page
182
ISSN
1872-7980
Published In/Presented At
Luo, Z., Wang, Q., Lau, W. B., Lau, B., Xu, L., Zhao, L., Yang, H., Feng, M., Xuan, Y., Yang, Y., Lei, L., Wang, C., Yi, T., Zhao, X., Wei, Y., & Zhou, S. (2016). Tumor microenvironment: The culprit for ovarian cancer metastasis?. Cancer letters, 377(2), 174–182. https://doi.org/10.1016/j.canlet.2016.04.038
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
27131957
Department(s)
Administration and Leadership
Document Type
Article