The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases.
Publication/Presentation Date
9-1-2015
Abstract
Adiponectin is an anti-atherogenic protein secreted by adipose cells that improves insulin sensitivity. Notably, adiponectin receptors are expressed in the brain, suggesting that adiponectin signaling disruption may impact neurologic function. Recently, studies have demonstrated the association of adiponectin levels with cerebrovascular disorders and neurodegenerative diseases (NDDs), and these results have drawn significant attention. In this review, we discuss the association between the adiponectin levels and the incidence, progression, and prognosis of cerebrovascular disorders and NDDs. We describe the controversial issues surrounding current studies and present our hypothesis concerning the possible mechanism underlying adiponectin function in neurological disorders. Finally, we explicate obstacles preventing clinical adiponectin administration, including available routes of drug delivery and the central nervous system regulation of adiponectin. Collectively, the data assembled herein serve as a comprehensive reference regarding the role of adiponectin in neurological disorders to support the future clinical potential of adiponectin as a therapeutic agent.
Volume
1852
Issue
9
First Page
1887
Last Page
1894
ISSN
0006-3002
Published In/Presented At
Yang, Y., Hu, W., Jiang, S., Wang, B., Li, Y., Fan, C., Di, S., Ma, Z., Lau, W. B., & Qu, Y. (2015). The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases. Biochimica et biophysica acta, 1852(9), 1887–1894. https://doi.org/10.1016/j.bbadis.2015.06.019
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
26118345
Department(s)
Administration and Leadership
Document Type
Article