Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress.
Publication/Presentation Date
1-1-2015
Abstract
The specific mechanisms underlying paraquat (PQ)-induced lung injury remain unknown, which limits understanding of its cytotoxic potential. Although oxidative stress has been established as an important mechanism underlying PQ toxicity, multiple antioxidants have proven ineffective in attenuating the deleterious effects of PQ. Adiponectin, which shows anti-oxidative and antinitrative effects, may have the potential to reduce PQ-mediated injury. The present study determined the protective action of globular domain adiponectin (gAd) on PQ-induced lung injury, and attempted to elucidate the underlying mechanism or mechanisms of action. BALB/c mice were administered PQ, with and without 12 or 36 h of gAd pre-treatment. The pulmonary oxidative/nitrative status was assessed by measuring pulmonary O
Volume
9
Issue
1
First Page
131
Last Page
136
ISSN
1792-0981
Published In/Presented At
Yao, R., Zhou, Y., He, Y., Jiang, Y., Liu, P., Ye, L., Zheng, Z., Lau, W. B., Cao, Y., & Zeng, Z. (2015). Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress. Experimental and therapeutic medicine, 9(1), 131–136. https://doi.org/10.3892/etm.2014.2073
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
25452788
Department(s)
Administration and Leadership
Document Type
Article