Role of Adipokines in Cardiovascular Disease.

Authors

• Wayne Bond Lau
• Koji Ohashi
• Yajing Wang
• Hayato Ogawa
• Toyoaki Murohara
• Xin-Liang Ma
• Noriyuki Ouchi

Publication/Presentation Date

6-23-2017

Abstract

Cardiovascular disease (CVD) is the greatest cause of death, accounting for nearly one-third of all deaths worldwide. The increase in obesity rates over 3 decades is widespread and threatens the public health in both developed and developing countries. Obesity, the excessive accumulation of visceral fat, causes the clustering of metabolic disorders, such as type 2 diabetes, dyslipidemia, and hypertension, culminating in the development of CVD. Adipose tissue is not only an energy storage organ, but an active endocrine tissue producing various biologically active proteins known as adipokines. Since leptin, a central regulator of food intake and energy expenditure, was demonstrated to be an adipose-specific adipokine, attention has focused on the identification and characterization of unknown adipokines to clarify the mechanisms underlying obesity-related disorders. Numerous adipokines have been identified in the past 2 decades; most adipokines are upregulated in the obese state. Adipokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and resistin are pro-inflammatory, and exacerbate various metabolic and cardiovascular diseases. However, a small number of adipokines, including adiponectin, are decreased by obesity, and generally exhibit antiinflammatory properties and protective functions against obesity-related diseases. Collectively, an imbalance in the production of pro- and antiinflammatory adipokines in the obese condition results in multiple complications. In this review, we focus on the pathophysiologic roles of adipokines with cardiovascular protective properties.

Volume

81

Issue

7

First Page

920

Last Page

928

ISSN

1347-4820

Published In/Presented At

Lau, W. B., Ohashi, K., Wang, Y., Ogawa, H., Murohara, T., Ma, X. L., & Ouchi, N. (2017). Role of Adipokines in Cardiovascular Disease. Circulation journal : official journal of the Japanese Circulation Society, 81(7), 920–928. https://doi.org/10.1253/circj.CJ-17-0458

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

28603178

Department(s)

Administration and Leadership

Document Type

Article