Surgical stress and cancer progression: the twisted tango.

Authors

• Zhiwei Chen
• Peidong Zhang
• Ya Xu
• Jiahui Yan
• Zixuan Liu
• Wayne Bond Lau
• Bonnie Lau
• Ying Li
• Xia Zhao
• Yuquan Wei
• Shengtao Zhou

Publication/Presentation Date

9-2-2019

Abstract

Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection potentially enhances metastatic seeding of tumor cells. In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. We also propose preventive strategies or resolution of tumor metastasis caused by surgical stress.

Volume

18

Issue

1

First Page

132

Last Page

132

ISSN

1476-4598

Published In/Presented At

Chen, Z., Zhang, P., Xu, Y., Yan, J., Liu, Z., Lau, W. B., Lau, B., Li, Y., Zhao, X., Wei, Y., & Zhou, S. (2019). Surgical stress and cancer progression: the twisted tango. Molecular cancer, 18(1), 132. https://doi.org/10.1186/s12943-019-1058-3

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

31477121

Department(s)

Administration and Leadership

Document Type

Article