Human immunoglobulin G mediates protective immunity and identifies protective antigens against larval Strongyloides stercoralis in mice.
Publication/Presentation Date
4-1-2004
Abstract
Protective immunity to larval Strongyloides stercoralis in mice has been shown to be dependent on antibody, complement, and granulocytes. The goals of the present study was to determine the following: (1) whether human serum could passively transfer immunity to mice, (2) the mechanism by which the serum mediated killing, and (3) whether the antigens (Ags) recognized by the protective human antibody could induce protective immunity in mice. Immunoglobulin G (IgG) from a S. stercoralis-seropositive individual passively transferred immunity to mice. The antibody required granulocytes, but not eosinophils, and complement activation to kill the larvae. Antibody-dependent cellular cytotoxicity was not required for larval killing. Immunization of mice with soluble larval Ags isolated by use of the protective immune IgG resulted in protective immunity. In conclusion, immunity could be transferred to mice by IgG from immune humans, and Ags identified by the immune human IgG induced protective immunity in mice, which thereby suggests their possible use in a vaccine against this infection.
Volume
189
Issue
7
First Page
1282
Last Page
1290
ISSN
0022-1899
Published In/Presented At
Kerepesi, L. A., Nolan, T. J., Schad, G. A., Lustigman, S., Herbert, D. R., Keiser, P. B., Nutman, T. B., Krolewiecki, A. J., & Abraham, D. (2004). Human immunoglobulin G mediates protective immunity and identifies protective antigens against larval Strongyloides stercoralis in mice. The Journal of infectious diseases, 189(7), 1282–1290. https://doi.org/10.1086/382484
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15031798
Department(s)
Administration and Leadership
Document Type
Article