Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model.
Publication/Presentation Date
12-1-2011
Abstract
Mice have been used to the study the mechanisms of protective innate and adaptive immunity to larval Strongyloides stercoralis. During primary infection, neutrophils and eosinophils are attracted by parasite components and kill the larvae by release of granule products. Eosinophils also function as antigen-presenting cells for the induction of a Th2 response. B cells produce both IgM and IgG that collaborate with neutrophils to kill worms in the adaptive immune response. Vaccine studies have identified a recombinant diagnostic antigen that induced high levels of immunity to infection with S. stercoralis in mice. These studies demonstrate that there are redundancies in the mechanisms used by the immune response to kill the parasite and that a vaccine with a single antigen may be suitable as a prophylactic vaccine to prevent human strongyloidiasis.
Volume
51
Issue
2-3
First Page
205
Last Page
214
ISSN
1559-0755
Published In/Presented At
Bonne-Année, S., Hess, J. A., & Abraham, D. (2011). Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model. Immunologic research, 51(2-3), 205–214. https://doi.org/10.1007/s12026-011-8258-2
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
22101674
Department(s)
Administration and Leadership
Document Type
Article