Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis.
Publication/Presentation Date
9-1-2013
Abstract
Macrophages are multifunctional cells that are active in TH1- and TH2-mediated responses. In this study, we demonstrate that human and mouse macrophages collaborate with neutrophils and complement to kill the parasite Strongyloides stercoralis in vitro. Infection of mice with worms resulted in the induction of alternatively activated macrophages (AAM) within the peritoneal cavity. These cells killed the worms in vivo and collaborated with neutrophils and complement during the in vitro killing process. AAM generated in vitro killed larvae more rapidly than naive macrophages, which killed larvae after a longer time period. In contrast, classically activated macrophages were unable to kill larvae either in vitro or in vivo. This study adds macrophages to the armamentarium of immune components that function in elimination of parasitic helminths and demonstrate a novel function by which AAM control large extracellular parasites.
Volume
81
Issue
9
First Page
3346
Last Page
3355
ISSN
1098-5522
Published In/Presented At
Bonne-Année, S., Kerepesi, L. A., Hess, J. A., O'Connell, A. E., Lok, J. B., Nolan, T. J., & Abraham, D. (2013). Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis. Infection and immunity, 81(9), 3346–3355. https://doi.org/10.1128/IAI.00625-13
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23798541
Department(s)
Administration and Leadership
Document Type
Article