Onchocerca volvulus: The Road from Basic Biology to a Vaccine.
Publication/Presentation Date
1-1-2018
Abstract
Human onchocerciasis - commonly known as river blindness - is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan Africa blind and/or with chronic disabilities. Attempts to eliminate onchocerciasis, primarily through the mass drug administration of ivermectin, remains challenging and has been heightened by the recent news that drug-resistant parasites are developing in some populations after years of drug treatment. Needed, and needed now, in the fight to eliminate onchocerciasis are new tools, such as preventive and therapeutic vaccines. This review summarizes the progress made to advance the onchocerciasis vaccine from the research laboratory into the clinic.
Volume
34
Issue
1
First Page
64
Last Page
79
ISSN
1471-5007
Published In/Presented At
Lustigman, S., Makepeace, B. L., Klei, T. R., Babayan, S. A., Hotez, P., Abraham, D., & Bottazzi, M. E. (2018). Onchocerca volvulus: The Road from Basic Biology to a Vaccine. Trends in parasitology, 34(1), 64–79. https://doi.org/10.1016/j.pt.2017.08.011
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
28958602
Department(s)
Administration and Leadership
Document Type
Article