Survival and development of larval Onchocerca volvulus in diffusion chambers implanted in primate and rodent hosts.
Publication/Presentation Date
8-1-1993
Abstract
Third-stage larvae (L3) of Onchocerca volvulus were implanted in diffusion chambers in chimpanzees, mangabey monkeys, rhesus monkeys, squirrel monkeys, and inbred strains of mice, jirds, and rats for 3-63 days. At different times during the experimental period, larvae were recovered and assessed for their viability and development. Survival and growth rates were equal regardless of whether the implanted larvae were fresh or cryopreserved. Survival and growth rates of the larvae did not differ among the primate and rodent hosts tested, with the exception of squirrel monkeys and rats, which were resistant to infection. Molting from L3 to fourth-stage larvae began on day 3 and continued through day 14 in the primates and rodents. The primate and rodent models developed in the present study will be useful for the study of the immunology and chemotherapy of onchocerciasis.
Volume
79
Issue
4
First Page
571
Last Page
582
ISSN
0022-3395
Published In/Presented At
Abraham, D., Lange, A. M., Yutanawiboonchai, W., Trpis, M., Dickerson, J. W., Swenson, B., & Eberhard, M. L. (1993). Survival and development of larval Onchocerca volvulus in diffusion chambers implanted in primate and rodent hosts. The Journal of parasitology, 79(4), 571–582.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8331478
Department(s)
Administration and Leadership
Document Type
Article