Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA.
Publication/Presentation Date
11-1-1996
Abstract
We have previously shown that C6 cells expressing an antisense insulin-like growth factor I receptor (IGF-IR) RNA are no longer tumorigenic in syngeneic rats, protecting them from subsequent subcutaneous tumor challenge and causing regression of established subcutaneous tumors. In the present study, we have investigated the efficacy of this strategy on intracerebrally implanted C6 rat glioblastoma cells. We demonstrate that C6 cells expressing an antisense IGF-IR RNA implanted for 24 h in the subcutaneous tissue of the rats are able to elicit an anti-tumor response in the brain, leading to complete brain tumor regression and long-term survival of the rats. These findings suggest the possibility of therapeutic intervention in human gliomas.
Volume
1
Issue
6
First Page
385
Last Page
389
ISSN
1359-4117
Published In/Presented At
Resnicoff, M., Tjuvajev, J., Rotman, H. L., Abraham, D., Curtis, M., Aiken, R., & Baserga, R. (1996). Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA. Journal of experimental therapeutics & oncology, 1(6), 385–389.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
9414429
Department(s)
Administration and Leadership
Document Type
Article