Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma.
Publication/Presentation Date
5-5-1988
Abstract
The proto-oncogene c-myc is the cellular homologue of the transforming sequence carried by the avian myelocytomastosis virus MC29. A growing body of evidence implicates structural and functional alterations in and around proto-oncogenes such as c-myc in tumorogenesis. Here we report that comparison of the structure of myc from a ductal adenocarcinoma of the breast and from normal breast tissue of the same patient (Sc) revealed a tumour-specific rearrangement of one myc locus and amplification of the other myc locus. (For myc reviews see refs 1-4; for myc involvement in breast neoplasia see refs 5-7.) Within the second intron of the rearranged locus was a non-myc sequence with nearly complete homology to a long interspersed repetitive element (a LINE-1 sequence or L1). In this case, the L1 sequence has functioned as a mobile genetic element to produce a somatic mutation.
Volume
333
Issue
6168
First Page
87
Last Page
90
ISSN
0028-0836
Published In/Presented At
Morse, B., Rotherg, P. G., South, V. J., Spandorfer, J. M., & Astrin, S. M. (1988). Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma. Nature, 333(6168), 87–90. https://doi.org/10.1038/333087a0
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2834650
Department(s)
Administration and Leadership
Document Type
Article