Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study.
Publication/Presentation Date
12-1-2025
Abstract
OBJECTIVE: This study aimed to examine the association of BMI with cognitive performance in individuals with diabetes or prediabetes.
METHODS: Among Diabetes Prevention Program Outcomes Study (DPPOS) participants, BMI was categorized as normal (< 25 kg/m
RESULTS: A total of 2285 participants (mean ± SD age 51.1 ± 10.0 years; 67.7% female; 31% with overweight; and 60% with obesity at DPPOS Y8) completed cognitive assessments. Those with overweight or obesity at Y8 had a slower decline in B-SEVLT immediate and delayed recall, compared with those with normal BMI; 3MS performance was higher among individuals with overweight or obesity compared to those with normal BMI at Y15.
CONCLUSIONS: Among individuals with prediabetes or diabetes in DPPOS, overweight or obesity was associated with slower decline in verbal learning and memory compared with those with normal BMI.
Volume
33
Issue
12
First Page
2365
Last Page
2376
ISSN
1930-739X
Published In/Presented At
Luchsinger, J. A., Pan, Q., Knowler, W. C., Munshi, M., Watson, K., Gadde, K. M., Schlögl, M., Carmichael, O. T., & DPP Research Group (2025). Association of BMI and Cognitive Performance in the Diabetes Prevention Program Outcomes Study. Obesity (Silver Spring, Md.), 33(12), 2365–2376. https://doi.org/10.1002/oby.70031
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
41017217
Department(s)
Administration and Leadership
Document Type
Article