The effect of intravenous lidoflazine on serotonin-induced cerebral vascular contraction--an in vivo study.
Publication/Presentation Date
1-1-1986
Abstract
Lidoflazine, a piperazine derivative with known selectivity for vascular smooth muscle, was evaluated as a possible agent for prophylaxis of cerebral vascular contraction induced by subarachnoid perfusion with serotonin. The animals treated with serotonin (5 X 10(-6) M), had a 60% reduction in the diameter of basilar artery but when pretreated with Lidoflazine (1 mg/kg) intravenously, only had a 20% reduction in diameter (p less than 0.01). Lidoflazine, when administered intravenously at a slow rate will not adversely lower systemic blood pressure and can prevent the contraction of cerebral vessels when the stimulus for contraction is in the subarachnoid space.
Volume
17
Issue
4
First Page
728
Last Page
730
ISSN
0039-2499
Published In/Presented At
Rosenwasser, R. H., Tuma, R. F., & Buchheit, W. A. (1986). The effect of intravenous lidoflazine on serotonin-induced cerebral vascular contraction--an in vivo study. Stroke, 17(4), 728–730. https://doi.org/10.1161/01.str.17.4.728
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
3738957
Department(s)
Administration and Leadership
Document Type
Article