The effect of intravenous lidoflazine on whole blood-induced basilar artery contraction. An in vivo study.
Publication/Presentation Date
6-1-1987
Abstract
Lidoflazine, a piperazine derivative of known selectivity for vascular smooth muscle, was evaluated as a possible agent for prophylaxis of cerebral vascular contraction induced by subarachnoid perfusion with whole blood. Previous studies from this laboratory have indicated its efficacy in preventing basilar artery contraction induced by serotonin. The animals treated with a subarachnoid perfusion of whole blood had a mean 30% reduction in vessel diameter over the control value. Groups that were treated with 0.5 mg/kg of lidoflazine and 1.0 mg/kg of lidoflazine and then perfused with whole blood in the subarachnoid space had reductions in control diameter of 2.8% and 6.8%, respectively. One group treated with 2.0 mg/kg of lidoflazine and then perfused with whole blood actually had an increase in diameter of 6.8% over the control value. Lidoflazine, when administered intravenously at a slow rate, will not adversely lower systemic blood pressure and can prevent the contraction of cerebral vessels when the stimulus for contraction is whole blood within the subarachnoid space.
Volume
27
Issue
6
First Page
533
Last Page
536
ISSN
0090-3019
Published In/Presented At
Rosenwasser, R. H., Tuma, R. F., Buchheit, W. A., & McDowell, A. (1987). The effect of intravenous lidoflazine on whole blood-induced basilar artery contraction. An in vivo study. Surgical neurology, 27(6), 533–536. https://doi.org/10.1016/0090-3019(87)90150-9
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
3576428
Department(s)
Administration and Leadership
Document Type
Article