Pharmacologic therapy of chronic heart failure.
Publication/Presentation Date
1-1-2007
Abstract
Over the past 2 decades, investigators have learned more about the pathophysiologic changes that occur in systolic and diastolic dysfunction. Ironically, in some cases, the biologic pathways that have protected the heart during acute dysfunction are the same pathways that cause progressive deleterious effects with chronic activation. In particular, it is the activation of the neurohormonal system that has a significant impact on disease progression. As a result, the neurohormonal system has provided a key target for pharmacologic therapy in patients with heart failure secondary to systolic dysfunction. These targets include the renin-angiotensin-aldosterone system as well as the sympathetic nervous system. Neurohormonal manipulation, however, is often ineffective in the pharmacologic therapy of patients with endstage heart failure, therefore other treatment strategies - including the use of inotropic agents to improve pump function and diuretics to control fluid balance are needed.
Volume
7
Issue
4
First Page
235
Last Page
248
ISSN
1175-3277
Published In/Presented At
Hamad, E., Mather, P. J., Srinivasan, S., Rubin, S., Whellan, D. J., & Feldman, A. M. (2007). Pharmacologic therapy of chronic heart failure. American journal of cardiovascular drugs : drugs, devices, and other interventions, 7(4), 235–248. https://doi.org/10.2165/00129784-200707040-00002
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
17696565
Department(s)
Administration and Leadership
Document Type
Article