Are there negative responders to exercise training among heart failure patients?
Publication/Presentation Date
2-1-2014
Abstract
PURPOSE: Aerobic exercise training has been used in patients with stable heart failure (HF) to reduce the risk of clinical events. However, due to patient heterogeneity, some patients may experience a decrease in functional capacity due to such training. The purpose of this study was to estimate the proportion of HF patients participating in a training program who had negative responses to such therapy and to compare them with a concurrent control group.
METHODS: Baseline and 3-month peak V˙O2 measurements were obtained on 1870 HF subjects who were randomized to receive either an exercise training program or a control program of usual care without exercise training. The exercise program consisted of supervised walking or stationary cycling 3 d·wk(-1) for 12 wk as well as a 2-d·wk(-1) home exercise program after completing 18 supervised sessions. A negative response was defined as a baseline-to-3-month decrease in peak V˙O2 of at least 5 mL·kg(-1) min(-1), which was two times the SD of the control group's change in peak V˙O2.
RESULTS: The mean ± SD change in peak V˙O2 in the exercise group and control group was 0.8 ± 2.5 mL·kg(-1)min(-1) and 0.2 ± 2.5 mL·kg(-1)min(-1), respectively (P < 0.001). The percentage of negative responders in the exercise and control groups was 0.9% and 2.3% (P = 0.02).
CONCLUSIONS: The low negative response rate in the exercise group combined with the slightly higher rate in the control group and equal variability in the exercise and control groups suggests that few if any subjects had training-related negative peak V˙O2 responses. These findings support current exercise recommendations for HF patients.
Volume
46
Issue
2
First Page
219
Last Page
224
ISSN
1530-0315
Published In/Presented At
Leifer, E. S., Brawner, C. A., Fleg, J. L., Kraus, W. E., Whellan, D. J., Piña, I. L., & Keteyian, S. J. (2014). Are there negative responders to exercise training among heart failure patients?. Medicine and science in sports and exercise, 46(2), 219–224. https://doi.org/10.1249/MSS.0b013e3182a44164
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23860416
Department(s)
Administration and Leadership
Document Type
Article