Regulation of microRNA-145 by growth arrest and differentiation.
Publication/Presentation Date
2-15-2011
Abstract
MicroRNA145 (miR145), a tumor suppressor miR, has been reported to inhibit growth of human cancer cells, to induce differentiation and to cause apoptosis, all conditions that result in growth arrest. In order to clarify the functional effects of miR145, we have investigated its expression in diverse conditions and different cell lines. Our results show that miR145 levels definitely increase in differentiating cells and also in growth-arrested cells, even in the absence of differentiation. Increased expression during differentiation sometimes occurs as a late event, suggesting that miR145 could be required either early or late during the differentiation process.
Volume
317
Issue
4
First Page
488
Last Page
495
ISSN
1090-2422
Published In/Presented At
La Rocca, G., Shi, B., Audia, A., Ferrari-Amorotti, G., Mellert, H. S., Calabretta, B., McMahon, S. B., Sepp-Lorenzino, L., & Baserga, R. (2011). Regulation of microRNA-145 by growth arrest and differentiation. Experimental cell research, 317(4), 488–495. https://doi.org/10.1016/j.yexcr.2010.11.010
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
21111732
Department(s)
Administration and Leadership
Document Type
Article