Dynamic regulation of mitochondrial transcription as a mechanism of cellular adaptation.
Publication/Presentation Date
1-1-2012
Abstract
Eukaryotes control nearly every cellular process in part by modulating the transcription of genes encoded by their nuclear genome. However, these cells are faced with the added complexity of possessing a second genome, within the mitochondria, which encodes critical components of several essential processes, including energy metabolism and macromolecule biosynthesis. As these cellular processes require gene products encoded by both genomes, cells have adopted strategies for linking mitochondrial gene expression to nuclear gene expression and other dynamic cellular events. Here we discuss examples of several mechanisms that have been identified, by which eukaryotic cells link extramitochondrial signals to dynamic alterations in mitochondrial transcription. This article is part of a Special Issue entitled: Mitochondrial Gene Expression.
Volume
1819
Issue
9-10
First Page
1075
Last Page
1079
ISSN
0006-3002
Published In/Presented At
Blomain, E. S., & McMahon, S. B. (2012). Dynamic regulation of mitochondrial transcription as a mechanism of cellular adaptation. Biochimica et biophysica acta, 1819(9-10), 1075–1079. https://doi.org/10.1016/j.bbagrm.2012.06.004
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
22766037
Department(s)
Administration and Leadership
Document Type
Article