MYC and the control of apoptosis.
Publication/Presentation Date
7-1-2014
Abstract
MYC expression is tightly correlated with cell-cycle progression in normal tissues, whereas unchecked MYC expression is among the most prominent hallmarks of the hyperproliferation associated with most forms of cancer. At first glance it might seem counterintuitive that MYC is also among the most robust agents of programmed cell death (apoptosis) in mammalian cells. However it is clearly beneficial for a multicellular organism to have a mechanism for triggering death in cells that express potentially oncogenic levels of MYC. Decades of intense study have begun to provide an understanding of the mechanisms that regulate MYC's seemingly split personality. Key features of MYC-induced apoptosis will be discussed here along with examples of how our understanding of this pathway might be exploited for the therapeutic benefit of cancer patients.
Volume
4
Issue
7
First Page
014407
Last Page
014407
ISSN
2157-1422
Published In/Presented At
McMahon S. B. (2014). MYC and the control of apoptosis. Cold Spring Harbor perspectives in medicine, 4(7), a014407. https://doi.org/10.1101/cshperspect.a014407
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
24985130
Department(s)
Administration and Leadership
Document Type
Article