Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells.
Publication/Presentation Date
11-1-2009
Abstract
Protein phosphorylation is regulated dynamically in eukaryotic cells via modulation of the enzymatic activity of kinases and phosphatases. Like phosphorylation, acetylation has emerged as a critical regulatory protein modification that is altered dynamically in response to diverse cellular cues. Moreover, acetyltransferases and deacetylases are tightly linked to cellular signaling pathways. Recent studies provide clues about the mechanisms utilized to regulate acetyltransferases and deacetylases. The therapeutic value of deacetylase inhibitors suggests that understanding acetylation pathways will directly impact our ability to rationally target these enzymes in patients. Recently discovered mechanisms that directly regulate the catalytic activity of acetyltransferases and deacetylases provide exciting new insights about these enzymes.
Volume
34
Issue
11
First Page
571
Last Page
578
ISSN
0968-0004
Published In/Presented At
Mellert, H. S., & McMahon, S. B. (2009). Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells. Trends in biochemical sciences, 34(11), 571–578. https://doi.org/10.1016/j.tibs.2009.06.010
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19819149
Department(s)
Administration and Leadership
Document Type
Article