Restricted clonality of visceral sarcomas in avian sarcoma virus-infected chickens.
Publication/Presentation Date
3-1-1989
Abstract
Experiments were undertaken to analyze proviral DNA in primary (wing web) and visceral sarcomas arising in FP chickens infected with BH-RSV(RAV-2). Using the degree of heterogeneity of BH-RSV proviral integration sites as a measure of the degree of polyclonality of sarcoma tissue, we observed that a high proportion of the visceral sarcomas examined comprised dominant clones, independently of whether these sarcomas were isolated from immune-suppressed or nonsuppressed infected chickens; by contrast, a marked heterogeneity of BH-RSV proviral integration sites was noted with primary sarcoma tissue. Several visceral sarcomas containing dominant clones were characterized by the integration of a deleted form of the BH-RSV provirus. In addition, all of the primary and visceral sarcomas exhibited sequences specific for the RAV-2 provirus, and both types of sarcoma tissue were competent for infectious sarcoma virus production.
Volume
169
Issue
1
First Page
110
Last Page
114
ISSN
0042-6822
Published In/Presented At
Halpern, M. S., McMahon, S. B., & Branco, F. (1989). Restricted clonality of visceral sarcomas in avian sarcoma virus-infected chickens. Virology, 169(1), 110–114. https://doi.org/10.1016/0042-6822(89)90046-9
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2538025
Department(s)
Administration and Leadership
Document Type
Article