Lung cancer-enriched p53 mutants occupy canonical p53 target genes without activating transcription, revealing a distinct loss-of-function behavior.

Authors

• Mason A Tracewell
• Hailey N Shankle
• Samantha M Barnada
• Khushali S Vyas
• Kevin M Kim
• Theodhora Qyshkollari
• Jonathan E Karlin
• Julie A Barta
• Steven B McMahon

Publication/Presentation Date

2-17-2026

Abstract

Lung cancer is the most common cause of cancer-related death in the U.S. and globally. Cigarette smoking remains the leading risk factor for lung cancer, in part by inducing loss-of-function mutations in tumor suppressor genes, including

ISSN

2692-8205

Published In/Presented At

Tracewell, M. A., Shankle, H. N., Barnada, S. M., Vyas, K. S., Kim, K. M., Qyshkollari, T., Karlin, J. E., Barta, J. A., & McMahon, S. B. (2026). Lung cancer-enriched p53 mutants occupy canonical p53 target genes without activating transcription, revealing a distinct loss-of-function behavior. bioRxiv : the preprint server for biology, 2026.02.14.705936. https://doi.org/10.64898/2026.02.14.705936

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

41756828

Department(s)

Administration and Leadership

Document Type

Article