Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisis.
Publication/Presentation Date
5-1-2000
Abstract
This prospective study was designed to examine the relationship between serial serum nitric oxide (NO) levels and pain during the emergency department (ED) treatment of acute vasoocclusive sickle cell crisis (SCC). 102 patient visits, age > or =18 years of age, presenting to the ED with uncomplicated, typical SCC pain had serum NO levels obtained at 2-hr intervals during treatment of pain and were measured using an NO-specific chemiluminesence technique. Pain was measured prior to each NO measurement using a 10 cm visual analog scale (VAS), and subjects were divided into a persistent pain group and an improved pain group. Patients with persistent pain had significantly low initial NO levels (11.51 microM +/- 2.8, P < 0.05) while those with pain improvement had higher initial NO levels (18.1 microM +/- 3.08, P < 0.05). There was no significant correlation between changes in NO and changes in pain scores. These results suggest that the initial NO level may serve as a marker for the severity of tissue ischemia. Sequential NO levels do not appear useful in predicting the course of SCC.
Volume
64
Issue
1
First Page
15
Last Page
19
ISSN
0361-8609
Published In/Presented At
Lopez, B. L., Davis-Moon, L., Ballas, S. K., & Ma, X. L. (2000). Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisis. American journal of hematology, 64(1), 15–19. https://doi.org/10.1002/(sici)1096-8652(200005)64:1<15::aid-ajh3>3.0.co;2-p
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
10815782
Department(s)
Administration and Leadership
Document Type
Article