Early anti-apoptosis treatment reduces myocardial infarct size after a prolonged reperfusion.
Publication/Presentation Date
9-1-2004
Abstract
OBJECTIVE: Significant myocardial apoptosis occurs in ischemia/reperfused hearts. However, the contribution of apoptosis to the development of myocardial injury remains controversial. The present study attempted to obtain evidence that inhibition of apoptosis at early reperfusion can reduce myocardial infarction after prolonged reperfusion.
METHODS: Adult male rats were subjected to 30 min ischemia and 4 (apoptosis assay) or 24 h (myocardial infarction determination) of reperfusion and treated with vehicle, SB 239063, insulin or insulin plus wortmannin.
RESULTS: Treatment with SB 239063 or insulin markedly decreased myocardial apoptosis (10.6 +/- 1.5% and 7.9 +/- 0.9% respectively, P < 0.01 vs. vehicle) and significantly reduced infarct size (43 +/- 3.6% and 35 +/- 2.9%, respectively, P < 0.01 vs. vehicle). Most interestingly, inhibition of insulin signaling with wortmannin to block insulin signaling not only blocked insulin's anti-apoptotic effect, but also abolished its infarct reduction property.
CONCLUSION: These data indicate that apoptosis contributes to the development of myocardial infarction, and inhibition of apoptosis at early reperfusion reduces the myocardial infarction.
Volume
9
Issue
5
First Page
553
Last Page
559
ISSN
1360-8185
Published In/Presented At
Gao, F., Tao, L., Yan, W., Gao, E., Liu, H. R., Lopez, B. L., Christopher, T. A., & Ma, X. L. (2004). Early anti-apoptosis treatment reduces myocardial infarct size after a prolonged reperfusion. Apoptosis : an international journal on programmed cell death, 9(5), 553–559. https://doi.org/10.1023/B:APPT.0000038035.75845.ab
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15314283
Department(s)
Administration and Leadership
Document Type
Article