Diagnostic and treatment modalities for autoimmune pancreatitis.
Publication/Presentation Date
9-1-2006
Abstract
Since the recognition of autoimmune pancreatitis (AIP) as a clinical entity, many advances have been made in defining clinical, radiologic, histologic, and laboratory parameters to assist in a complete definition of the disease. Despite all these efforts, a preoperative diagnosis still remains a clinical challenge but is of paramount importance, as these cases have been reported to be steroid-responsive; therefore, early treatment may obviate the need for surgical resection. Although the utilization of recently proposed guidelines by the Japanese Pancreas Society and an Italian study group may further assist the clinician and prompt the initiation of steroid treatment, the response to therapy should be observed within 2 to 4 weeks and reflected in progressive resolution of the presenting radiologic and laboratory abnormalities. Should these fail to demonstrate improvement, the diagnosis of AIP should undergo re-evaluation, and consideration for surgical exploration should be made, as the patient may be harboring a malignancy. Surgical resection in the form of pylorus-preserving pancreaticoduodenectomy remains the optimal solution in the attempt to clarify the diagnosis and offer treatment with low complication rates.
Volume
9
Issue
5
First Page
377
Last Page
384
ISSN
1092-8472
Published In/Presented At
Rao, A. S., Palazzo, F., Chung, J., Hager, E., Abdollahi, H., & Yeo, C. J. (2006). Diagnostic and treatment modalities for autoimmune pancreatitis. Current treatment options in gastroenterology, 9(5), 377–384. https://doi.org/10.1007/BF02738526
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
16942662
Department(s)
Administration and Leadership
Document Type
Article