HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tract.
Publication/Presentation Date
1-1-2005
Abstract
HLA-G belongs to the nonclassical MHC class Ib group of molecules and has been implicated in mediating immune-responsiveness in various cancerous and non-cancerous cell types. We have examined HLA-G expression in a number of human gastrointestinal malignancies, including pancreatic ductal adenocarcinoma, ampullary cancer, biliary cancer, and colorectal cancer by immunolabeling analysis. We used indices of < 5% (negative), 6-25%, 26-50%, 51-75%, and >75% (diffuse) to subclassify lesions based on percentage of positive cell labeling. Across all cancer subtypes, 52-79% of lesions demonstrated expression of HLA-G, with up to 33% of lesions demonstrating diffuse (>75%) expression. In addition, we utilized the neoplastic progression model of colorectal cancer to evaluate HLA-G protein expression in normal colon, tubulovillous adenomas, invasive cancer, and liver metastases arising from colorectal cancer. Focal HLA-G expression was detected in regions of normal colon adjacent to sites of adenomatous and cancerous lesions, as well as in all stages of cancer progression. Overall, the percentage of diffusely (>75%) labeled lesions appeared increased in preneoplastic and neoplastic conditions, as compared to normal colon. Specifically, tubulovillous adnenomas demonstrated pronounced diffuse labeling in 58% of lesions examined. No correlation with HLA-G expression and CD4+ or CD8+ T cells was identified. We propose that HLA-G expression is upregulated in a large percentage of gastrointestinal lesions and may serve to mediate immune-responsiveness in certain instances.
Volume
35
Issue
1
First Page
15
Last Page
23
ISSN
1537-3649
Published In/Presented At
Hansel, D. E., Rahman, A., Wilentz, R. E., Shih, I.eM., McMaster, M. T., Yeo, C. J., & Maitra, A. (2005). HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tract. International journal of gastrointestinal cancer, 35(1), 15–23. https://doi.org/10.1385/ijgc:35:1:015
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15722570
Department(s)
Administration and Leadership
Document Type
Article