Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject review.
Publication/Presentation Date
2-1-2005
Abstract
Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.
Volume
9
Issue
2
First Page
270
Last Page
279
ISSN
1091-255X
Published In/Presented At
Matsen, S. L., Yeo, C. J., Hruban, R. H., & Choti, M. A. (2005). Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject review. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 9(2), 270–279. https://doi.org/10.1016/j.gassur.2004.06.012
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15694824
Department(s)
Administration and Leadership
Document Type
Article