Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.
Publication/Presentation Date
8-15-2017
Abstract
Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenvironment. Here we illustrate how such conditions promote chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Glucose or glutamine withdrawal resulted in a 5- to 10-fold protective effect with chemotherapy treatment. PDAC xenografts were less sensitive to gemcitabine in hypoglycemic mice compared with hyperglycemic mice. Consistent with this observation, patients receiving adjuvant gemcitabine (
Volume
77
Issue
16
First Page
4460
Last Page
4471
ISSN
1538-7445
Published In/Presented At
Zarei, M., Lal, S., Parker, S. J., Nevler, A., Vaziri-Gohar, A., Dukleska, K., Mambelli-Lisboa, N. C., Moffat, C., Blanco, F. F., Chand, S. N., Jimbo, M., Cozzitorto, J. A., Jiang, W., Yeo, C. J., Londin, E. R., Seifert, E. L., Metallo, C. M., Brody, J. R., & Winter, J. M. (2017). Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. Cancer research, 77(16), 4460–4471. https://doi.org/10.1158/0008-5472.CAN-17-0015
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
28652247
Department(s)
Administration and Leadership
Document Type
Article