Chronic Obstructive Pulmonary Disease Is Associated with Worse Oncologic Outcomes in Early-Stage Resected Pancreatic and Periampullary Cancers.

Authors

• Rachel Huang
• Emma Hammelef
• Matthew Sabitsky
• Carolyn Ream
• Saed Khalilieh
• Nitzan Zohar
• Harish Lavu
• Wilbur B Bowne
• Charles J Yeo
• Avinoam Nevler

Publication/Presentation Date

6-10-2023

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer mortality in the United States. Hypoxic and hypercapnic tumor microenvironments have been suggested to promote tumor aggressiveness. The objective of this study was to evaluate the association between chronic obstructive pulmonary disease (COPD) and oncologic survival outcomes in patients with early-stage PDAC and periampullary cancers. In this case-control study, patients who underwent a pancreaticoduodenectomy during 2014-2021 were assessed. Demographic, perioperative, histologic, and oncologic data were collected. A total of 503 PDAC and periampullary adenocarcinoma patients were identified, 257 males and 246 females, with a mean age of 68.1 (±9.8) years and a mean pre-operative BMI of 26.6 (±4.7) kg/m

Volume

11

Issue

6

ISSN

2227-9059

Published In/Presented At

Huang, R., Hammelef, E., Sabitsky, M., Ream, C., Khalilieh, S., Zohar, N., Lavu, H., Bowne, W. B., Yeo, C. J., & Nevler, A. (2023). Chronic Obstructive Pulmonary Disease Is Associated with Worse Oncologic Outcomes in Early-Stage Resected Pancreatic and Periampullary Cancers. Biomedicines, 11(6), 1684. https://doi.org/10.3390/biomedicines11061684

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

37371779

Department(s)

Administration and Leadership

Document Type

Article