Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP.

Authors

• Satish R Tiyyagura
• Shiva Kazerounian
• Stephanie Schulz
• Scott A Waldman
• Giovanni M Pitari

Publication/Presentation Date

1-1-2004

Abstract

Calcium and guanosine-3',5'-cyclic monophosphate (cGMP) are second messenger molecules that regulate opposing physiological functions, reflected in the reciprocal regulation of their intracellular concentrations, in many systems. Indeed, cGMP and Ca2+ constitute discrete points of integration between multiple cell signaling cascades in both convergent and parallel pathways. This chapter describes the molecular mechanisms regulating intracellular Ca2+ and cGMP, and their integration in specific cellular responses.

Volume

69

First Page

69

Last Page

94

ISSN

0083-6729

Published In/Presented At

Tiyyagura, S. R., Kazerounian, S., Schulz, S., Waldman, S. A., & Pitari, G. M. (2004). Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP. Vitamins and hormones, 69, 69–94. https://doi.org/10.1016/S0083-6729(04)69003-0

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

15196879

Department(s)

Administration and Leadership

Document Type

Article