Current trends in targeting the hormonal regulation of appetite and energy balance to treat obesity.
Publication/Presentation Date
9-1-2010
Abstract
With the eruption of the obesity pandemic over the past few decades, much research has been devoted to understanding the molecular mechanisms by which the human body regulates energy balance. These studies have revealed several mediators, including gut/pancreatic/adipose hormones and neuropeptides that control both short- and long-term energy balance by regulating appetite and/or metabolism. These endogenous mediators of energy balance have been the focus of many anti-obesity drug-development programs aimed at either amplifying endogenous anorexigenic/lipolytic signaling or blocking endogenous orexigenic/lipogenic signaling. Here, we discuss the efficacy and safety of targeting these pathways for the pharmacologic treatment of obesity.
Volume
5
Issue
5
First Page
765
Last Page
783
ISSN
1744-6651
Published In/Presented At
Valentino, M. A., Colon-Gonzalez, F., Lin, J. E., & Waldman, S. A. (2010). Current trends in targeting the hormonal regulation of appetite and energy balance to treat obesity. Expert review of endocrinology & metabolism, 5(5), 765–783. https://doi.org/10.1586/eem.10.33
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
21297878
Department(s)
Administration and Leadership
Document Type
Article