Gut-Brain Endocrine Axes in Weight Regulation and Obesity Pharmacotherapy.

Authors

• Dante J Merlino
• Erik S Blomain
• Amanda S Aing
• Scott A Waldman

Publication/Presentation Date

7-15-2014

Abstract

In recent years, the obesity epidemic has developed into a major health crisis both in the United States as well as throughout the developed world. With current treatments limited to expensive, high-risk surgery and minimally efficacious pharmacotherapy, new therapeutic options are urgently needed to combat this alarming trend. This review focuses on the endogenous gut-brain signaling axes that regulate appetite under physiological conditions, and discusses their clinical relevance by summarizing the clinical and preclinical studies that have investigated manipulation of these pathways to treat obesity.

Volume

3

Issue

3

First Page

763

Last Page

794

ISSN

2077-0383

Published In/Presented At

Merlino, D. J., Blomain, E. S., Aing, A. S., & Waldman, S. A. (2014). Gut-Brain Endocrine Axes in Weight Regulation and Obesity Pharmacotherapy. Journal of clinical medicine, 3(3), 763–794. https://doi.org/10.3390/jcm3030763

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

26237477

Department(s)

Administration and Leadership

Document Type

Article