GUCY2C ligand replacement to prevent colorectal cancer.
Publication/Presentation Date
7-2-2016
Abstract
Despite advances in screening and prevention strategies, colorectal cancer (CRC) remains the second-leading cause of cancer-related death in the United States. Given this continued public health burden of CRC, there is a clear need for improved disease prevention. CRC initiates and progresses over decades, canonically proceeding via a series of stepwise molecular events that turn a normal epithelium into a dysfunctional epithelium, then subsequently into an adenoma, and finally an invasive adenocarcinoma. An emerging paradigm suggests that guanylyl cyclase C (GUCY2C) functions as a tumor suppressor in the intestine, and that the loss of hormone ligands for this receptor causes epithelial dysfunction and represents an important step in the disease process. In that context, GUCY2C ligand replacement therapy has been proposed as a strategy to prevent colorectal cancer, a translational opportunity that is underscored by the recent regulatory approval of the oral GUCY2C ligand linaclotide (Linzess™, Forest Laboratories and Ironwood Pharmaceuticals, Inc.).
Volume
17
Issue
7
First Page
713
Last Page
718
ISSN
1555-8576
Published In/Presented At
Blomain, E. S., Pattison, A. M., & Waldman, S. A. (2016). GUCY2C ligand replacement to prevent colorectal cancer. Cancer biology & therapy, 17(7), 713–718. https://doi.org/10.1080/15384047.2016.1178429
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
27104761
Department(s)
Administration and Leadership
Document Type
Article