GUCY2C maintains intestinal LGR5

Authors

• Crystal L Kraft
• Jeffrey A Rappaport
• Adam E Snook
• Amanda M Pattison
• John P Lynch
• Scott A Waldman

Publication/Presentation Date

11-28-2017

Abstract

Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes to accommodate normal maintenance and post-injury regeneration of the epithelium. Their long life, lineage plasticity, and proliferative potential underlie the necessity for tight homeostatic regulation of the ISC compartment. In that context, the guanylate cyclase C (GUCY2C) receptor and its paracrine ligands regulate intestinal epithelial homeostasis, including proliferation, lineage commitment, and DNA damage repair. However, a role for this axis in maintaining ISCs remains unknown. Transgenic mice enabling analysis of ISCs (

Volume

8

Issue

61

First Page

102923

Last Page

102933

ISSN

1949-2553

Published In/Presented At

Kraft, C. L., Rappaport, J. A., Snook, A. E., Pattison, A. M., Lynch, J. P., & Waldman, S. A. (2017). GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress. Oncotarget, 8(61), 102923–102933. https://doi.org/10.18632/oncotarget.22084

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

29262534

Department(s)

Administration and Leadership

Document Type

Article