Stem cells as therapeutic targets in colorectal cancer.
Publication/Presentation Date
3-1-2021
Abstract
Colorectal cancer continues to represent a significant burden on public health as the second highest cause of cancer mortality, when men and women are combined, in the US. About 50% of patients either present with late-stage metastatic disease, or develop metastatic recurrences, and ultimately die. In turn, this mortality largely reflects cancer stem cells, tumor-initiating cells that are responsible for cancer progression, drug resistance, recurrence and metastasis. This review summarizes the unique properties of colorectal cancer stem cells, and the emerging strategies by which they can be selectively targeted as a therapeutic approach to eradicating this disease.
Volume
18
Issue
2
First Page
171
Last Page
183
ISSN
1744-828X
Published In/Presented At
Zalewski, A., Snook, A. E., & Waldman, S. A. (2021). Stem cells as therapeutic targets in colorectal cancer. Personalized medicine, 18(2), 171–183. https://doi.org/10.2217/pme-2020-0099
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33565332
Department(s)
Administration and Leadership
Document Type
Article