Targeting molecular and genetic pathways driving tumorigenesis for precision therapy in colorectal cancer.

Authors

• Allison S Doermann
• Adi Caspi
• Andrew E Evans
• Andrea Feci
• Ariana A Entezari
• Adam E Snook
• Scott A Waldman

Publication/Presentation Date

12-31-2026

Abstract

Colorectal cancer (CRC) remains a major global health challenge and a leading cause of cancer-related mortality worldwide. Central to its pathogenesis is the dysregulation of interconnected signal transduction networks that govern cellular proliferation, survival, differentiation, apoptosis, and immune modulation. Progressive disruption of these pathways facilitates malignant transformation of the colonic epithelium and underlies disease initiation and progression. In this review, we examine the foundational signaling mechanisms implicated in CRC, with an emphasis on the Wnt/β-catenin, GUCY2C, MAPK/ERK, p53, PI3K/AKT, and SMAD4/TGF-

Volume

27

Issue

1

First Page

2683096

Last Page

2683096

ISSN

1555-8576

Published In/Presented At

Doermann, A. S., Caspi, A., Evans, A. E., Feci, A., Entezari, A. A., Snook, A. E., & Waldman, S. A. (2026). Targeting molecular and genetic pathways driving tumorigenesis for precision therapy in colorectal cancer. Cancer biology & therapy, 27(1), 2683096. https://doi.org/10.1080/15384047.2026.2683096

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

42502958

Department(s)

Administration and Leadership

Document Type

Article