A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer.
Publication/Presentation Date
4-1-2009
Abstract
There is emerging evidence of the production in human tumors of abnormal levels of microRNAs (miRNAs), which have been assigned oncogenic and/or tumor-suppressor functions. While some miRNAs commonly exhibit altered amounts across tumors, more often, different tumor types produce unique patterns of miRNAs, related to their tissue of origin. The role of miRNAs in tumorigenesis underscores their value as mechanism-based therapeutic targets in cancer. Similarly, unique patterns of altered levels of miRNA production provide fingerprints that may serve as molecular biomarkers for tumor diagnosis, classification, prognosis of disease-specific outcomes and prediction of therapeutic responses.
Volume
276
Issue
8
First Page
2157
Last Page
2164
ISSN
1742-4658
Published In/Presented At
Waldman, S. A., & Terzic, A. (2009). A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer. The FEBS journal, 276(8), 2157–2164. https://doi.org/10.1111/j.1742-4658.2009.06934.x
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19250312
Department(s)
Administration and Leadership
Document Type
Article