Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics.
Publication/Presentation Date
8-1-2010
Abstract
Heat-stable toxins (STs) produced by enterotoxigenic bacteria cause endemic and traveler's diarrhea by binding to and activating the intestinal receptor guanylyl cyclase C (GC-C). Advances in understanding the biology of GC-C have extended ST from a diarrheagenic peptide to a novel therapeutic agent. Here, we summarize the physiological and pathophysiological role of GC-C in fluid-electrolyte regulation and intestinal crypt-villus homeostasis, as well as describe translational opportunities offered by STs, reflecting the unique characteristics of GC-C, in treating irritable bowel syndrome and chronic constipation, and in preventing and treating colorectal cancer.
Volume
2
Issue
8
First Page
2028
Last Page
2054
ISSN
2072-6651
Published In/Presented At
Lin, J. E., Valentino, M., Marszalowicz, G., Magee, M. S., Li, P., Snook, A. E., Stoecker, B. A., Chang, C., & Waldman, S. A. (2010). Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics. Toxins, 2(8), 2028–2054. https://doi.org/10.3390/toxins2082028
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
22069671
Department(s)
Administration and Leadership
Document Type
Article