Regulation of appetite to treat obesity.

Authors

• Gilbert W Kim
• Jieru E Lin
• Michael A Valentino
• Francheska Colon-Gonzalez
• Scott A Waldman

Publication/Presentation Date

3-1-2011

Abstract

Obesity has escalated into a pandemic over the past few decades. In turn, research efforts have sought to elucidate the molecular mechanisms underlying the regulation of energy balance. A host of endogenous mediators regulate appetite and metabolism, and thereby control both short- and long-term energy balance. These mediators, which include gut, pancreatic and adipose neuropeptides, have been targeted in the development of anti-obesity pharmacotherapy, with the goal of amplifying anorexigenic and lipolytic signaling or blocking orexigenic and lipogenic signaling. This article presents the efficacy and safety of these anti-obesity drugs.

Volume

4

Issue

2

First Page

243

Last Page

259

ISSN

1751-2441

Published In/Presented At

Kim, G. W., Lin, J. E., Valentino, M. A., Colon-Gonzalez, F., & Waldman, S. A. (2011). Regulation of appetite to treat obesity. Expert review of clinical pharmacology, 4(2), 243–259. https://doi.org/10.1586/ecp.11.3

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

21666781

Department(s)

Administration and Leadership

Document Type

Article