GUCY2C: at the intersection of obesity and cancer.
Publication/Presentation Date
4-1-2013
Abstract
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. Recent discoveries expand the homeostatic role of GUCY2C to reveal a novel gut-brain endocrine axis regulating appetite, anchored by hypothalamic GUCY2C which is responsive to intestine-derived uroguanylin. Thus, GUCY2C may represent a new target for anti-obesity pharmacotherapy. Moreover, the coincident regulation of energy balance and tumor suppression by a single hormone receptor system suggests that the GUCY2C axis might contribute to the established relationship between obesity and colorectal cancer. This confluence suggests that hormone supplementation to reconstitute GUCY2C signaling may be an elegant strategy to reverse both pathophysiologic processes.
Volume
24
Issue
4
First Page
165
Last Page
173
ISSN
1879-3061
Published In/Presented At
Kim, G. W., Lin, J. E., & Waldman, S. A. (2013). GUCY2C: at the intersection of obesity and cancer. Trends in endocrinology and metabolism: TEM, 24(4), 165–173. https://doi.org/10.1016/j.tem.2013.01.001
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23375388
Department(s)
Administration and Leadership
Document Type
Article