Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture.
Publication/Presentation Date
1-1-2012
Abstract
Smoking is an established risk factor for subarachnoid hemorrhage yet the underlying mechanisms are largely unknown. Recent data has implicated a role of inflammation in the development of cerebral aneurysms. Inflammation accompanying cigarette smoke exposure may thus be a critical pathway underlying the development, progression, and rupture of cerebral aneurysms. Various constituents of the inflammatory response appear to be involved including adhesion molecules, cytokines, reactive oxygen species, leukocytes, matrix metalloproteinases, and vascular smooth muscle cells. Characterization of the molecular basis of the inflammatory response accompanying cigarette smoke exposure will provide a rational approach for future targeted therapy. In this paper, we review the current body of knowledge implicating cigarette smoke-induced inflammation in cerebral aneurysm formation/rupture and attempt to highlight important avenues for future investigation.
Volume
2012
First Page
271582
Last Page
271582
ISSN
1466-1861
Published In/Presented At
Chalouhi, N., Ali, M. S., Starke, R. M., Jabbour, P. M., Tjoumakaris, S. I., Gonzalez, L. F., Rosenwasser, R. H., Koch, W. J., & Dumont, A. S. (2012). Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture. Mediators of inflammation, 2012, 271582. https://doi.org/10.1155/2012/271582
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23316103
Department(s)
Administration and Leadership
Document Type
Article