Recombinant human osteogenic protein-1 (bone morphogenetic protein-7) as an osteoinductive agent in spinal fusion.
Publication/Presentation Date
8-15-2002
Abstract
STUDY DESIGN: The data related to spinal applications of osteogenic protein-1 presented at national meetings or published in peer-reviewed literature are reviewed.
OBJECTIVES: To review the available data related to the use of osteogenic protein-1 for spinal arthrodesis. REVIEW OF BACKGROUND DATA: Osteogenic protein-1 (bone morphogenetic protein-7) is a member of the bone morphogenetic protein family and has shown strong osteoinductivity in vivo.
METHODS: The background related to osteogenic protein-1 for spinal applications and the known studies presented at national meetings or published in the peer-reviewed literature are reviewed.
RESULTS: Osteogenic protein-1 is able to achieve solid bony fusion of the spine in both the anterior and posterolateral environments in animal studies and has a good safety profile. Early human trials appear to be promising.
CONCLUSIONS: Animal studies support the ability of osteogenic protein-1 to enhance or replace autograft for spinal arthrodesis in both the posterolateral and interbody environment. Human trials ultimately will provide data to clarify the optimal role of osteogenic protein-1 in human spinal surgery.
Volume
27
Issue
16 Suppl 1
First Page
59
Last Page
65
ISSN
1528-1159
Published In/Presented At
Vaccaro, A. R., Anderson, D. G., & Toth, C. A. (2002). Recombinant human osteogenic protein-1 (bone morphogenetic protein-7) as an osteoinductive agent in spinal fusion. Spine, 27(16 Suppl 1), S59–S65. https://doi.org/10.1097/00007632-200208151-00013
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
12205422
Department(s)
Administration and Leadership
Document Type
Article