Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis.
Publication/Presentation Date
4-1-2019
Abstract
The pathophysiology of spinal cord injury (SCI) related processes of axonal degeneration and demyelination are poorly understood. The present systematic review and meta-analysis were performed such to establish quantitative results of animal studies regarding the role of injury severity, SCI models and level of injury on the pathophysiology of axon and myelin sheath degeneration. 39 related articles were included in the analysis. The compiled data showed that the total number of axons, number of myelinated axons, myelin sheath thickness, axonal conduction velocity, and internode length steadily decreased as time elapsed from the injury (P
Volume
97
First Page
9
Last Page
22
ISSN
1873-6300
Published In/Presented At
Hassannejad, Z., Yousefifard, M., Azizi, Y., Zadegan, S. A., Sajadi, K., Sharif-Alhoseini, M., Shakouri-Motlagh, A., Mokhatab, M., Rezvan, M., Shokraneh, F., Hosseini, M., Vaccaro, A. R., Harrop, J. S., & Rahimi-Movaghar, V. (2019). Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis. Journal of chemical neuroanatomy, 97, 9–22. https://doi.org/10.1016/j.jchemneu.2019.01.009
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
30726717
Department(s)
Administration and Leadership
Document Type
Article