Impact of surface roughness and bulk porosity on spinal interbody implants.
Publication/Presentation Date
2-1-2023
Abstract
Spinal fusion surgeries are performed to treat a multitude of cervical and lumbar diseases that lead to pain and disability. Spinal interbody fusion involves inserting a cage between the spinal vertebrae, and is often utilized for indirect neurologic decompression, correction of spinal alignment, anterior column stability, and increased fusion rate. The long-term success of interbody fusion relies on complete osseointegration between the implant surface and vertebral end plates. Titanium (Ti)-based alloys and polyetheretherketone (PEEK) interbody cages represent the most commonly utilized materials and provide sufficient mechanics and biocompatibility to assist in fusion. However, modification to the surface and bulk characteristics of these materials has been shown to maximize osseointegration and long-term stability. Specifically, the introduction of intrinsic porosity and surface roughness has been shown to affect spinal interbody mechanics, vascularization, osteoblast attachment, and ingrowth potential. This narrative review synthesizes the mechanical, in vitro, in vivo, and clinical effects on fusion efficacy associated with introduction of porosity in Ti (neat and alloy) and PEEK intervertebral implants.
Volume
111
Issue
2
First Page
478
Last Page
489
ISSN
1552-4981
Published In/Presented At
Levy, H. A., Karamian, B. A., Yalla, G. R., Canseco, J. A., Vaccaro, A. R., & Kepler, C. K. (2023). Impact of surface roughness and bulk porosity on spinal interbody implants. Journal of biomedical materials research. Part B, Applied biomaterials, 111(2), 478–489. https://doi.org/10.1002/jbm.b.35161
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
36075112
Department(s)
Administration and Leadership
Document Type
Article