The impact of demineralized bone matrix characteristics on pseudarthrosis and surgical outcomes after posterolateral lumbar decompression and fusion.

Authors

• Jeremy C Heard
• Yunsoo Lee
• Mark J Lambrechts
• Emily Berthiaume
• Nicholas D D'Antonio
• John Bodnar
• John Paulik
• John J Mangan
• Jose A Canseco
• Mark F Kurd
• I David Kaye
• Alexander R Vaccaro
• Christopher K Kepler
• Gregory D Schroeder
• Alan S Hilibrand

Publication/Presentation Date

1-1-2023

Abstract

OBJECTIVES: The objectives of our study were to compare the fusion rates and surgical outcomes of lumbar fusion surgery based on the (1) type of demineralized bone matrix (DBM) carrier allograft, (2) the presence/absence of a carrier, and (3) the presence of bone fibers in DBM.

METHODS: Patients >18 years of age who underwent single-level posterolateral decompression and fusion (PLDF) between L3 and L5 between 2014 and 2021 were retrospectively identified. We assessed bone grafts based on carrier type (no carrier, sodium hyaluronate carrier, and glycerol carrier) and the presence of bone fibers. Fusion status was determined based on a radiographic assessment of bony bridging, screw loosening, or change in segmental lordosis >5°. Analyses were performed to assess fusion rates and surgical outcomes.

RESULTS: Fifty-four patients were given DBM with a hyaluronate carrier, 75 had a glycerol carrier, and 94 patients were given DBM without a carrier. DBM carrier type, bone fibers, and carrier presence had no impact on 90-day readmission rates (

CONCLUSION: Our study found no significant differences between DBM containing glycerol, sodium hyaluronate, or no carrier regarding fusion rates or surgical outcomes after single-level PLDF. Bone particulates versus bone fibers also had no significant differences regarding the likelihood of bony fusion.

Volume

14

Issue

2

First Page

194

Last Page

200

ISSN

0974-8237

Published In/Presented At

Heard, J. C., Lee, Y., Lambrechts, M. J., Berthiaume, E., D'Antonio, N. D., Bodnar, J., Paulik, J., Mangan, J. J., Canseco, J. A., Kurd, M. F., Kaye, I. D., Vaccaro, A. R., Kepler, C. K., Schroeder, G. D., & Hilibrand, A. S. (2023). The impact of demineralized bone matrix characteristics on pseudarthrosis and surgical outcomes after posterolateral lumbar decompression and fusion. Journal of craniovertebral junction & spine, 14(2), 194–200. https://doi.org/10.4103/jcvjs.jcvjs_45_23

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

37448499

Department(s)

Administration and Leadership

Document Type

Article