GLP-1 Receptor Agonists in Orthopaedic Surgery: Implications for Perioperative Care and Outcomes: An Orthopaedic Surgeon's Perspective.
Publication/Presentation Date
7-10-2025
Abstract
➢ Glucagon-like peptide-1 (GLP-1) receptor agonists are a promising tool for preoperative weight loss in the patient who is undergoing orthopaedic surgery and has concomitant obesity and type-2 diabetes mellitus.➢ With regard to the perioperative management of GLP-1 receptor agonists for the orthopaedic surgeon, the American Society of Anesthesiologists (ASA) recommends withholding daily-dose GLP-1 therapy on the day of the elective surgical procedure and withholding weekly-dose therapy for the week prior to the procedure.➢ The ASA recommends postponing surgery or proceeding with "full stomach precautions" if the patient undergoing an orthopaedic procedure and taking GLP-1 therapy exhibits gastrointestinal symptoms on the day of the elective procedure.➢ In the trauma setting, patients taking GLP-1 therapy should proceed with the surgical procedure at the discretion of the surgeon with full stomach precautions or a preoperative point-of-care gastric ultrasound.➢ GLP-1 receptor agonists show the potential for disease modification in osteoarthritis and osteoporosis.
Volume
107
Issue
16
First Page
1879
Last Page
1886
ISSN
1535-1386
Published In/Presented At
Ramanathan, R., Lee, J. Y., Dalton, J. F., Lin, R. T., Lee, I., Gonzalez, C., Jr, Shaw, J. D., Schroeder, G. D., Kepler, C. K., Spitnale, M., Vaccaro, A. R., Gabrielli, A. S., & Wawrose, R. A. (2025). GLP-1 Receptor Agonists in Orthopaedic Surgery: Implications for Perioperative Care and Outcomes: An Orthopaedic Surgeon's Perspective. The Journal of bone and joint surgery. American volume, 107(16), 1879–1886. https://doi.org/10.2106/JBJS.24.01287
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
40833394
Department(s)
Administration and Leadership
Document Type
Article