Depression and psychotic disorders worsen perioperative outcomes and increase resource utilization after multilevel lumbar fusion: Implications for screening and perioperative care.
Publication/Presentation Date
1-1-2026
Abstract
CONTEXT: Multilevel lumbar fusion use has increased with an aging U.S. population. Depression and psychotic disorders are linked to poorer surgical outcomes, but their effects in this setting are unclear.
AIMS: The aims of this study were to quantify the prevalence of these disorders and evaluate associations with perioperative outcomes and resource use.
SETTINGS AND DESIGN: This was a retrospective cohort study using the National Inpatient Sample from 2016 to 2022.
SUBJECTS AND METHODS: Depression and psychotic disorders were defined using Elixhauser-derived indicators. Outcomes included medical and mechanical complications, discharge disposition, length of stay (LOS), and costs.
STATISTICAL ANALYSIS USED: Chi-square and logistic regression analyses were performed, with significance at the
RESULTS: Among 458,180 weighted admissions, 18.6% had depression and 2.5% had psychoses. Compared to patients without these diagnoses, depression was associated with higher odds of cardiovascular complications (odds ratio [OR]: 1.25,
CONCLUSIONS: Depression and psychotic disorders are common among patients undergoing multilevel lumbar fusion and are associated with higher healthcare utilization.
Volume
17
Issue
2
First Page
138
Last Page
144
ISSN
0974-8237
Published In/Presented At
Mastrokostas, L. E., Mastrokostas, P. G., Schwartz, L. B., Razi, A., Inzerillo, S., Houten, J. K., Varthi, A., Vaccaro, A. R., Monsef, J. B., Razi, A. E., & Ng, M. K. (2026). Depression and psychotic disorders worsen perioperative outcomes and increase resource utilization after multilevel lumbar fusion: Implications for screening and perioperative care. Journal of craniovertebral junction & spine, 17(2), 138–144. https://doi.org/10.4103/jcvjs.jcvjs_214_25
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
41929745
Department(s)
Administration and Leadership
Document Type
Article