The Biological Response of Human NP Cells to Soluble Collagen VI.

Authors

• Jonathan Dalton
• Srikanth N Divi
• Yasmine K Eichbaum
• Panya Luksanapruksa
• Mitchell K Ng
• Rachel Huang
• Alan S Hilibrand
• Alexander R Vaccaro
• Dessislava Z Markova
• Christopher K Kepler

Publication/Presentation Date

7-26-2026

Abstract

Extracellular matrix (ECM) dysregulation plays a significant role in the development of intervertebral disc disease (IVDD). The ECM around the chondrocytes in the nucleus pulposus (NP) is unique in that it contains ColVI. While linked to chondrocyte proliferation in cartilage, ColVI's specific role in IVD degeneration is less clear. Our aim was to determine the expression of ColVI in NP cells from degenerative IVDs, along with the effects of soluble ColVI on NP cells. Thus, we compared the expression levels of ColVI in human degenerated IVD samples, along with the effect of soluble ColVI on primary human NP cells. A higher Pfirrmann grade was associated with increased

Volume

15

Issue

15

ISSN

2073-4409

Published In/Presented At

Dalton, J., Divi, S. N., Eichbaum, Y. K., Luksanapruksa, P., Ng, M. K., Huang, R., Hilibrand, A. S., Vaccaro, A. R., Markova, D. Z., & Kepler, C. K. (2026). The Biological Response of Human NP Cells to Soluble Collagen VI. Cells, 15(15), 1339. https://doi.org/10.3390/cells15151339

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

42587749

Department(s)

Administration and Leadership

Document Type

Article