Symptom Duration of One Year or More Is Associated With Worse Absolute Outcomes but Similar Clinically Meaningful Improvement After ACDF for Cervical Myelopathy.

Authors

• Yulia Lee
• Gregorio Baek
• Mitchell Ng
• Jonathan Dalton
• Morgan Hitchner
• Yasmine Eichbaum
• William A Green
• Joshua Mathew
• Alec Giakas
• Grant Thomas
• Alan Hilibrand
• Alexander Vaccaro
• Thomas Cha
• Gregory Schroeder
• Christopher Kepler

Publication/Presentation Date

8-15-2026

Abstract

STUDY DESIGN: Retrospective cohort study.

OBJECTIVE: To evaluate the association between preoperative symptom duration and neurologic and patient-reported outcomes after anterior cervical discectomy and fusion (ACDF) for degenerative cervical myelopathy (DCM).

SUMMARY OF BACKGROUND DATA: Prior studies suggest longer duration of preoperative myelopathic symptoms may impair neurologic recovery after surgery, but its relationship with patient-reported outcome measures (PROMs) and clinically meaningful improvement remains unclear.

METHODS: Adult patients undergoing primary ACDF for myelopathy at a single academic institution (2017-2023) were identified. Patients were stratified by symptom duration (< 1 y vs. ≥1 y). Demographic, surgical, and clinical outcomes were collected. PROMs included Short Form-12 mental and physical component scores (MCS, PCS), Visual Analog Scale (VAS) Neck and Arm, Neck Disability Index (NDI), and modified Japanese Orthopaedic Association (mJOA) scores collected preoperatively and at 3, 6, and 12 months postoperatively. Achievement of minimal clinically important difference (MCID) was assessed.

RESULTS: A total of 139 patients met inclusion criteria, including 75 (54.0%) with symptom duration < 1 year. Patients with < 1 year of symptoms were older, less likely to have commercial insurance, less likely to undergo inpatient surgery, and underwent fusion of fewer levels. Six-month MCS (55.1 vs. 50.2, P =0.038) and 3-month PCS (38.5 vs. 34.3, P =0.030) were greater in the < 1-year cohort. VAS Neck and NDI scores were lower at select postoperative time points in the < 1-year cohort. The ≥1-year cohort demonstrated higher rates of MCID achievement for VAS Neck at 6 and 12 months. No differences were observed in mJOA scores or MCID achievement for other outcomes.

CONCLUSIONS: Longer preoperative symptom duration was associated with worse absolute postoperative pain and disability but not neurologic recovery, with largely comparable rates of MCID achievement after ACDF. These findings suggest that delayed presentation does not preclude meaningful postoperative improvement for cervical myelopathy.

LEVEL OF EVIDENCE: Level III.

Volume

51

Issue

16

First Page

1130

Last Page

1139

ISSN

1528-1159

Published In/Presented At

Lee, Y., Baek, G., Ng, M., Dalton, J., Hitchner, M., Eichbaum, Y., Green, W. A., Mathew, J., Giakas, A., Thomas, G., Hilibrand, A., Vaccaro, A., Cha, T., Schroeder, G., & Kepler, C. (2026). Symptom Duration of One Year or More Is Associated With Worse Absolute Outcomes but Similar Clinically Meaningful Improvement After ACDF for Cervical Myelopathy. Spine, 51(16), 1130–1139. https://doi.org/10.1097/BRS.0000000000005751

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

42202763

Department(s)

Administration and Leadership

Document Type

Article